fumarato de proscalina

Proscaline Fumarate – Scientific Product Documentation

🔬Especificaciones químicas

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

Parámetros principales:

• Nombre IUPAC : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• Fórmula molecular : C₁₃H₂₁NO₃ · C₄H₄O₄

• Peso molecular : 339.36 g/mol

• Pureza : ≥98% (HPLC-UV at 254 nm)

• Forma : White crystalline powder

• Melting point : 172-174°C (decomposes)

• Solubilidad :15 mg/ml en agua, 30 mg/ml en etanol tibio

🧫Aplicaciones de investigación

1. Estudios de unión a receptores :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. Análisis de la vía metabólica :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. Datos toxicológicos :

   • DL₅₀ (rata, oral): 320 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. espectro de efectos secundarios :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. Interacciones críticas :

   • Peligroso : MAO inhibitors, sympathomimetics

   • Arriesgado : Serotonergic agents, vasopressors

📉Datos de estabilidad

• Duración : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• espectro de masas : [M+H]⁺ 240.2 m/z

• UV absorption :λmáx 282 nm (ε = 4200)

❓Research-oriented FAQ

P1: ¿Cuál es el mecanismo de acción?
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

Q2: How does the potency compare to mescaline?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌Limitaciones de la investigación

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.