Proskalín fumarát

Proscaline Fumarate – Scientific Product Documentation

🔬Chemical Specifications

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

Core parameters:

• Názov IUPAC : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• Molekulárny vzorec C₁₃H₂₁NO₃ · C₄H₄O₄

• Molekulová hmotnosť : 339.36 g/mol

• Čistota : ≥98% (HPLC-UV at 254 nm)

• Formulár : White crystalline powder

• Melting point : 172-174°C (decomposes)

• Rozpustnosť 15 mg/ml vo vode, 30 mg/ml v teplom etanole

🧫Výskumné aplikácie

1. Štúdie väzby na receptory :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. Analýza metabolických dráh :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. Toxicological data :

   • LD₅₀ (rat, oral): 320 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. Side effect spectrum :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. Critical Interactions :

   • Dangerous : MAO inhibitors, sympathomimetics

   • Risky : Serotonergic agents, vasopressors

📉Údaje o stabilite

• Trvanlivosť : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• Mass spectrum : [M+H]⁺ 240.2 m/z

• UV absorption λmax 282 nm (ε = 4200)

❓Research-oriented FAQ

Q1: What is the mechanism of action?
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

Q2: How does the potency compare to mescaline?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌Research limitations

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.