Fumarato de metililescalina

Methallylescaline Fumarate – Scientific Product Documentation

🔬Especificações Químicas

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.

Parâmetros principais:

• Nome IUPAC : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate

• Fórmula molecular : C₁₄H₂₁NO₃ · C₄H₄O₄

• Peso molecular : 351.38 g/mol

• Pureza : ≥97% (HPLC-UV at 280 nm)

• Aparência : White to light beige crystalline powder

• Melting point : 158-160°C (decomposes)

• Solubilidade : 12 mg/ml em água, 25 mg/ml em etanol

🧪Aplicações Científicas

1. Pesquisa neurofarmacológica :

   • 5-HT₂A receptor affinity studies (Ki = 85 nM)

   • Comparative analyses with mescaline and allylescaline

2. Psychometric evaluations :

   • Perceptual effects in controlled animal studies

   • Dose-response relationships in mammalian models

3. Metabolic studies :

   • O-demethylation kinetics study

   • CYP enzyme interaction profile

⚖️Recommended Dosages for Research

Diretrizes experimentais:

*Note: Non-linear pharmacokinetics above 4 mg/kg*

⚠️Safety Aspects & Risks

1. Dados toxicológicos :

   • LD₅₀ (rat, oral): 290 mg/kg

   • NOAEL: 0.5 mg/kg/day (14-day study)

2. Side effect profile :

   • <2 mg/kg: Minimal physiological effects

   • 2-5 mg/kg: Increased sensory sensitivity

   • 5 mg/kg: Potential cardiovascular effects

3. Interações Críticas :

   • Perigoso : MAO inhibitors, serotonergic agents

   • Arriscado : Antihypertensives, QT-prolonging medications

📊Controle de Qualidade e Dados Analíticos

• Pureza HPLC : 97.3% (C18 column, 65:35 H₂O:MeCN)

• Residual solvents : <0.2% (GC-MS)

• Dados de estabilidade :

  • Shelf life: 18 months at -20°C

  • Room temperature: 3 months (under argon)

❓Perguntas frequentes sobre pesquisa

Q1: Qual é o mecanismo de ação?
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).

Q3: What are the optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <500 μM, but limited chromosome test data.

📌Limitações da pesquisa

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies pharmacokinetics

🔍Conclusion for Scientists

Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.

Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.