{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/onderzoekschemicals.com\/?post_type=product&p=23378"},"modified":"2025-06-30T11:38:45","modified_gmt":"2025-06-30T11:38:45","slug":"escaline-hydrochloride","status":"publish","type":"product","link":"https:\/\/onderzoekschemicals.com\/hr\/shop\/bijna-verboden\/escaline-hydrochloride\/","title":{"rendered":"Eskalin hidroklorid"},"content":{"rendered":"

Eskalin hidroklorid \u2013 Znanstvena dokumentacija o proizvodu<\/strong><\/h3>\n

\ud83d\udd2c Kemijske specifikacije<\/strong><\/h4>\n

Eskalin (4-etoksi-3,5-dimetoksifenetilamin) hidroklorid je polusintetski derivat fenetilamina strukturno sli\u010dan meskalinu. Ovaj istra\u017eiva\u010dki spoj se prou\u010dava zbog svog zanimljivog farmakolo\u0161kog profila.<\/p>\n

Osnovni parametri:<\/em><\/p>\n

    \n
  • \n

    Naziv po IUPAC-u<\/strong>2-(4-etoksi-3,5-dimetoksifenil)etan-1-amin hidroklorid<\/p>\n<\/li>\n

  • \n

    Molekularna formula<\/strong>C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Molekularna te\u017eina<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

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    \u010cisto\u0107a<\/strong>: \u226598% (HPLC-UV na 280 nm)<\/p>\n<\/li>\n

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    Oblik<\/strong>Bijeli kristalni prah<\/p>\n<\/li>\n

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    To\u010dka taljenja<\/strong>: 243-245\u00b0C (raspada se)<\/p>\n<\/li>\n

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    Topljivost<\/strong>50 mg\/ml u vodi, 30 mg\/ml u metanolu<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Znanstvene primjene<\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakolo\u0161ka istra\u017eivanja<\/strong>:<\/p>\n

        \n
      • \n

        Studije vezanja 5-HT\u2082A receptora (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        Komparativne studije meskalina i drugih fenetilamina<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Bihevioralna istra\u017eivanja<\/strong>:<\/p>\n

          \n
        • \n

          Utjecaji na pona\u0161anje \u017eivotinja u kontroliranim uvjetima<\/p>\n<\/li>\n

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          Odnosi doze i odgovora u modelima sisavaca<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Metaboli\u010dke studije<\/strong>:<\/p>\n

            \n
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            Studija kinetike O-dealkilacije<\/p>\n<\/li>\n

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            Profil interakcije CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Preporu\u010dene doze za istra\u017eivanje<\/strong><\/h4>\n

            Eksperimentalne smjernice:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nDoziranje<\/th>\nAdministrativna cesta<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nMedij za stani\u010dnu kulturu<\/td>\n<\/tr>\n
            Male \u017eivotinje<\/td>\n1-5 mg\/kg<\/td>\nIntraperitonealno<\/td>\n<\/tr>\n
            Primati<\/td>\n0,2-1 mg\/kg<\/td>\nOralno<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Napomena: U\u010dinci ovisni o dozi iznad 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Sigurnosni aspekti i rizici<\/strong><\/h4>\n
              \n
            1. \n

              Toksikolo\u0161ki podaci<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (mi\u0161, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/dan (28-dnevna studija)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Profil nuspojava<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimalni fiziolo\u0161ki u\u010dinci<\/p>\n<\/li>\n

                • \n

                  2-6 mg\/kg: Senzorna modulacija<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potencijalni hemodinamski u\u010dinci<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kriti\u010dne interakcije<\/strong>:<\/p>\n

                    \n
                  • \n

                    Opasno<\/strong>MAO inhibitori, serotonergi\u010dki agensi<\/p>\n<\/li>\n

                  • \n

                    Riskantno<\/strong>Vazokonstriktori, antipsihotici<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kontrola kvalitete i analiti\u010dki podaci<\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC \u010disto\u0107a<\/strong>98.2% (kolona C18, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Preostala otapala<\/strong><0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Podaci o stabilnosti<\/strong>:<\/p>\n

                        \n
                      • \n

                        Rok trajanja: 24 mjeseca na -20\u00b0C<\/p>\n<\/li>\n

                      • \n

                        Sobna temperatura: 6 mjeseci (pod argonom)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 \u010cesto postavljana istra\u017eiva\u010dka pitanja<\/strong><\/h4>\n

                        P1: Koji je mehanizam djelovanja?<\/strong>
                        \nA: Primarno djelovanje kao agonist 5-HT\u2082A receptora sa sekundarnim u\u010dincima na dopaminergi\u010dke sustave.<\/p>\n

                        P2: Kako se ja\u010dina djelovanja uspore\u0111uje s meskalinom?<\/strong>
                        \nA: Otprilike 1,5 puta ve\u0107i afinitet receptora, ali dulje trajanje djelovanja (8-10 sati).<\/p>\n

                        P3: Koji su optimalni uvjeti skladi\u0161tenja?<\/strong>
                        \nA: U jantarnim bo\u010dicama pod inertnim plinom na -20\u00b0C.<\/p>\n

                        P4: Postoje li genotoksi\u010dni rizici?<\/strong>
                        \nA: Amesov test negativan pri <1 mM, ali ograni\u010deni podaci o kromosomskom testu.<\/p>\n

                        \ud83d\udccc Ograni\u010denja istra\u017eivanja<\/strong><\/h4>\n
                          \n
                        • \n

                          Ograni\u010deni podaci o kroni\u010dnoj izlo\u017eenosti<\/p>\n<\/li>\n

                        • \n

                          Nepoznati u\u010dinci na neuroplasti\u010dnost<\/p>\n<\/li>\n

                        • \n

                          Varijabilni me\u0111uvrsni metabolizam<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Zaklju\u010dak za znanstvenike<\/strong><\/h4>\n

                          Eskalin hidroklorid nudi vrijedne mogu\u0107nosti za komparativna istra\u017eivanja serotonina, s jedinstvenom kombinacijom stabilnosti i dugotrajnosti. Oblik hidroklorida jam\u010di izvrsnu topljivost za laboratorijske primjene.<\/p>\n

                          Va\u017eno odricanje od odgovornosti: Ovaj je proizvod namijenjen isklju\u010divo za znanstvena istra\u017eivanja u akreditiranim laboratorijima. Nije za ljudsku upotrebu ili dijagnosti\u010dke primjene. Svi eksperimenti moraju se provoditi u skladu s lokalnim propisima i eti\u010dkim smjernicama.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Svojstva eskalin hidroklorida<\/span><\/h3>\n

                          Sinonim:<\/strong> 3,5-dimetoksi-4-etoksifenetilamin hidroklorid
                          \nCAS broj:<\/strong> 39201-82-6
                          \nFormula:<\/strong> 2-{3,5-dimetoksi-4-etiloksifenil}etan-1-amin hidroklorid
                          \nMolarna masa:<\/strong> 261,8 g\/mol
                          \n\u010cisto\u0107a:<\/strong> >97%<\/p>","protected":false},"featured_media":20228,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/media\/20228"}],"wp:attachment":[{"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/onderzoekschemicals.com\/hr\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"radni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}