Proskaliinifumaraatti

Proscaline Fumarate – Scientific Product Documentation

🔬Kemialliset tiedot

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally similar to mescaline. This research compound is being studied for its unique receptor interaction profile.

Ydinparametrit:

• IUPAC-nimi : 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate

• Molekyylikaava C₁₃H₂₁NO₃ · C₄H₄O₄

• Molekyylipaino : 339.36 g/mol

• Puhtaus : ≥98% (HPLC-UV at 254 nm)

• Lomake : White crystalline powder

• Melting point : 172-174°C (decomposes)

• Liukoisuus 15 mg/ml vedessä, 30 mg/ml lämpimässä etanolissa

🧫Tutkimussovellukset

1. Reseptorien sitoutumistutkimukset :

   • 5-HT₂A agonism (EC₅₀ = 280 nM)

   • Dopaminergic modulation research

2. Neurophysiological examination :

   • EEG pattern analysis in experimental animals

   • Comparative studies with classical psychedelics

3. Aineenvaihduntareittien analyysi :

   • O-demethylation kinetics

   • CYP2D6 interaction profile

⚗️Experimental Protocols

Standard research conditions:

*Note: Show non-linear pharmacokinetics above 8 mg/kg*

⚠️Safety profile

1. Toksikologiset tiedot :

   • LD₅₀ (rotta, suun kautta): 320 mg/kg

   • NOAEL: 0.75 mg/kg/day (28-day study)

2. Sivuvaikutusten kirjo :

   • Dose-dependent effects:

     • <3 mg/kg: Subtle sensory changes

     • 3-6 mg/kg: Vegetative symptoms

     • 6 mg/kg: Potential hemodynamic instability

3. Kriittiset vuorovaikutukset :

   • Vaarallinen : MAO inhibitors, sympathomimetics

   • Riskialtis : Serotonergic agents, vasopressors

📉Vakaustiedot

• Säilyvyysaika : 24 months at -20°C (under argon)

• Degradation products : <2% after 12 months RT

• Compatible buffers : PBS (pH 7.4), hydrochloric acid (0.1N)

🔍Analytical Features

• HPLC retention time : 6.8 min (C18, 70:30 H₂O:MeCN)

• Massaspektri : [M+H]⁺ 240.2 m/z

• UV absorption λmax 282 nm (ε = 4200)

❓Research-oriented FAQ

K1: Mikä on vaikutusmekanismi?
A: Primary 5-HT₂A receptor partial agonist with secondary DAT interaction.

Q2: How does the potency compare to mescaline?
A: ~3x higher 5-HT₂A affinity but lower blood-brain barrier penetration.

Q3: Are there genotoxic risks?
A: Ames test negative up to 1 mM, but limited chromosome test data.

Q4: What is the optimal formulation?
A: Sterile saline (0.9% NaCl) for in vivo studies.

📌Tutkimuksen rajoitukset

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies metabolism

Scientific disclaimer: This product is intended solely for research use in accredited laboratories. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.